Culturing vaccines is a very tedious process and requires precision, or the vaccine becomes non effective. There are two types of ways vaccines are made; they are either cell based, which is more useful and easier, or made in a fertilized chicken egg: "Cell-based flu vaccines are being developed as an alternative to the egg-based manufacturing process. Cell culture technology is potentially more flexible than the traditional technology, which relies upon adequate supply of eggs" (CDC). Vaccines are made to ultimately protect (make someone immune) someone from a strand of virus or bacteria (I say a strand and not broadly just say virus/bacteria because of possible mutations that the virus/bacteria could undergo, requiring a new vaccine). Cell based vaccine culturing and egg based culturing requires only three steps, but must be done correctly. The first step is to grow the antigen inside a cell or a fertilized egg; bacterias, though, have to be grown in bioreactors: " Viruses are grown in primary cells (i.e. chicken eggs for the influenza vaccine), or on continuous cell lines (i.e. human cultured cells for hepatitis b vaccine); bacteria is grown in bioreactors (i.e. Hib vaccine)" (Colorado Children's Immunization Coalition). The second step involves isolating the antigen and obtaining it: "Antigen is isolated from the cells used to create it" (Colorado Children's Immunization Coalition). The last step involves "adding adjuvant, stabilizers and preservatives" (Colorado Children's Immunization Coalition) which serve multiple purposes in helping the body become immune to the antigen. adjuvants will increase the response of your immune system, stabilizers "increase vaccine storage life" (Colorado Children's Immunization Coalition), and preservatives allow for the vial to be given in multi doses. Though, after the vaccine is created, it doesn't get released to the public. The vaccine gets delivered to the FDA and undergoes rigorous testing. The reason why it must go through tests is because the side effects need to be recorded, there needs to be an approval of its safety, and it has to actually be proven that it serves its complete purpose. (237)
Josh is correct where he explained that they culture the vaccines mostly in egg and are ultimately made to protect individuals. Vaccines are made using the disease-causing virus or bacteria, but in a form that will not harm your child. Instead, the weakened, killed, or partial virus or bacteria prompts your baby’s immune system to develop antibodies, or defenders, against the disease. Vaccine is made by adding adjuvant, stabilizers and preservatives. Adjuvants increase immune response of the antigen; stabilizers increase the vaccine’s storage life; and preservatives allow for the use of multi-dose vials. The vaccines are both cell based or made in a fertilized chicken egg, but most still are made using the chicken egg.
Dibs - Papi Chulo aka Josh
ReplyDeleteDibs - Papi Chulo aka Josh
ReplyDeleteCulturing vaccines is a very tedious process and requires precision, or the vaccine becomes non effective. There are two types of ways vaccines are made; they are either cell based, which is more useful and easier, or made in a fertilized chicken egg: "Cell-based flu vaccines are being developed as an alternative to the egg-based manufacturing process. Cell culture technology is potentially more flexible than the traditional technology, which relies upon adequate supply of eggs" (CDC). Vaccines are made to ultimately protect (make someone immune) someone from a strand of virus or bacteria (I say a strand and not broadly just say virus/bacteria because of possible mutations that the virus/bacteria could undergo, requiring a new vaccine). Cell based vaccine culturing and egg based culturing requires only three steps, but must be done correctly. The first step is to grow the antigen inside a cell or a fertilized egg; bacterias, though, have to be grown in bioreactors: " Viruses are grown in primary cells (i.e. chicken eggs for the influenza vaccine), or on continuous cell lines (i.e. human cultured cells for hepatitis b vaccine); bacteria is grown in bioreactors (i.e. Hib vaccine)" (Colorado Children's Immunization Coalition). The second step involves isolating the antigen and obtaining it: "Antigen is isolated from the cells used to create it" (Colorado Children's Immunization Coalition). The last step involves "adding adjuvant, stabilizers and preservatives" (Colorado Children's Immunization Coalition) which serve multiple purposes in helping the body become immune to the antigen. adjuvants will increase the response of your immune system, stabilizers "increase vaccine storage life" (Colorado Children's Immunization Coalition), and preservatives allow for the vial to be given in multi doses. Though, after the vaccine is created, it doesn't get released to the public. The vaccine gets delivered to the FDA and undergoes rigorous testing. The reason why it must go through tests is because the side effects need to be recorded, there needs to be an approval of its safety, and it has to actually be proven that it serves its complete purpose. (237)
ReplyDeleteWhy kinds of tests does the FDA do on the flu vaccine?
DeleteJosh is correct where he explained that they culture the vaccines mostly in egg and are ultimately made to protect individuals. Vaccines are made using the disease-causing virus or bacteria, but in a form that will not harm your child. Instead, the weakened, killed, or partial virus or bacteria prompts your baby’s immune system to develop antibodies, or defenders, against the disease. Vaccine is made by adding adjuvant, stabilizers and preservatives. Adjuvants increase immune response of the antigen; stabilizers increase the vaccine’s storage life; and preservatives allow for the use of multi-dose vials. The vaccines are both cell based or made in a fertilized chicken egg, but most still are made using the chicken egg.
ReplyDelete